Volume : 7, Issue : 9, September - 2018

APOPTOTIC INDEX- A PROGNOSTIC PARAMETER IN ENDOMETRIAL LESIONS - HYPERPLASIA AND CARCINOMAS

Dr Natasha Makkar

Abstract :

<p class="MsoNormal" style="margin-bottom:12.0pt;line-height:200%;mso-pagination:&#10;none;mso-layout-grid-align:none;text-autospace:none"><b><span lang="EN-GB" style="mso-bidi-font-family:Times;color:black">Background</span></b><span lang="EN-GB" style="mso-bidi-font-family:Times;color:black;mso-bidi-font-weight:&#10;bold">:</span><span lang="EN-GB" style="mso-fareast-font-family:&quot;Times New Roman&quot;;&#10;mso-bidi-font-family:&quot;Times New Roman&quot;;color:#2A2A2A;background:white;&#10;mso-fareast-language:EN-GB">Endometrial cancer is the most common gynaecological malignancy affecting women in developed countries and the second most common gynaecological malignancy world-wide.</span><span lang="EN-GB" style="color:black;mso-themecolor:text1">The apoptotic index, defined as the percentage of morphologically identified apoptotic cells per 100 non apoptotic cells</span><span lang="EN-GB" style="mso-bidi-font-family:Times;color:black;&#10;mso-bidi-font-weight:bold">.</span><span lang="EN-GB" style="mso-bidi-font-family:&#10;&quot;Times New Roman&quot;;mso-fareast-language:EN-GB">Apoptosis is observed at increasing levels in the hyperplasia, atypia, adenocarcinoma sequence</span><b><span lang="EN-GB" style="mso-bidi-font-family:Times;color:black">. Methods</span></b><span lang="EN-GB" style="mso-bidi-font-family:Times;color:black;mso-bidi-font-weight:&#10;bold">: </span><span lang="EN-GB" style="mso-bidi-font-family:&quot;Times New Roman&quot;;&#10;color:black">In all hysterectomy cases, histological findings and apoptotic index was noted. The cases were divided into five categories. Mean apoptotic index was calculated in each category and comparison was done.</span><b><span lang="EN-GB" style="mso-bidi-font-family:Times;color:black">Results:</span></b><span lang="EN-GB" style="mso-bidi-font-family:&quot;Times New Roman&quot;;color:black">Edometrialcarcinoma had significantly higher apoptotic index than other categories (p-value =0.000). An increasing mean apoptotic index was noted in complex hyperplasia categories than in simple hyperplasia ones. </span><b><span lang="EN-GB" style="mso-bidi-font-family:&#10;Times;color:black">Conclusion</span></b><span lang="EN-GB" style="mso-bidi-font-family:&#10;Times;color:black;mso-bidi-font-weight:bold">: Apoptotic index gradually increases with increasing complexicity in endometrium.<o:p></o:p></span></p>