Volume : 7, Issue : 9, September - 2018

Pregnancy-Associated Atypical Hemolytic-Uremic Syndrome

Dr. Sonam Jadhav, Dr. Shaifali Patil

Abstract :

<p class="MsoNormal"><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Pregnancy is associated with various forms of thrombotic microangiopathy, including hemolytic uremic syndrome. Atypical haemolytic uraemic syndrome is one of the main variants of thrombotic microangiopathy, and is characterised by excessive complement activation in the </span><span lang="EN-IN"><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/microvessel" title="Learn more about Microvessel"><span style="font-size:14.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:windowtext;text-decoration:&#10;none;text-underline:none">microvasculature</span></a></span><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">. Pregnancy-associated atypical hemolytic-uremic syndrome (p-aHUS) is a rare condition characterized by microangiopathichemolyticanemia, thrombocytopenia, and acute kidney injury. Triggered by pregnancy, genetically predisposed women develop the syndrome, leading to a disastrous hemolytic disease characterized by diffuse endothelial damage and platelet consumption [1].<o:p></o:p></span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Being one of the </span><span lang="EN-IN"><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/differential-diagnosis" title="Learn more about Differential diagnosis"><span style="font-size:14.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:windowtext;&#10;text-decoration:none;text-underline:none">differential diagnoses</span></a></span><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> of </span><span lang="EN-IN"><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/pre-eclampsia" title="Learn more about Pre-eclampsia"><span style="font-size:14.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:windowtext;&#10;text-decoration:none;text-underline:none">preeclampsia&ndash;eclampsia and</span></a><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/hellp-syndrome" title="Learn more about HELLP syndrome"><span style="font-size:14.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:windowtext;&#10;text-decoration:none;text-underline:none">HELLP syndrome</span></a></span><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> the clinician must be familiar with the disease due to its high mortality, which can be modified with </span><span lang="EN-IN"><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/early-diagnosis" title="Learn more about Early Diagnosis"><span style="font-size:14.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:windowtext;&#10;text-decoration:none;text-underline:none">early diagnosis</span></a></span><span lang="EN-IN" style="font-size:14.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> and comprehensive treatment. The authors have here reported a case of atypical haemolytic uremic syndrome diagnosed postnatal. <o:p></o:p></span></p>