Volume : 7, Issue : 9, September - 2018

A study of role of neoadjuvant chemotherapy in downstaging of large operable breast cancer in Central India

Dr. M. M. Borkar, Dr. A. M. Quraishi, Dr. Dikpal Jadhav

Abstract :

<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;line-height:200%"><b><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;mso-bidi-font-style:&#10;italic">Objective:</span></b><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">&nbsp;&nbsp;To study of <span style="mso-bidi-font-weight:bold">role of neoadjuvant chemotherapy in downstaging of large operable east cancer in Central India<o:p></o:p></span></span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;line-height:200%"><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">.<b><span style="mso-bidi-font-style:italic">Materials andMethods:</span></b>&nbsp;</span><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;">This was a hospital based prospective nonrandomised study of 32 patients of large operable east cancer (lobc) conducted at a tertiary centre for a period of 2 years from January 2015 to December 2017<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;line-height:200%"><b><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;mso-bidi-font-style:&#10;italic">Results:</span></b><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">&nbsp;Maximum patients were in age group of 41-50 with mean age of presentation being 43.73 years and median age of presentation 43.5 years. Most women i.e. 23 (71.88%) were premenopausal.Most patients 24(75%) achieved maximal tumour response after 4 cycles of neoadjuvant chemotherapy. 24 patients (75%) had partical clinical response and 4 had complete clinical response.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;line-height:200%"><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">.<b><span style="mso-bidi-font-style:italic">Conclusions:</span></b><span style="mso-bidi-font-weight:bold;mso-bidi-font-style:italic">Neoadjuvant chemotherapy reduces the size of lump in LOBC.<o:p></o:p></span></span></p>