Volume : 7, Issue : 9, September - 2018

Relationship between polytherapy due to memory impairment in childhood epilepsy patients

Scorpicanrus Tumpal Andreas, Johannes Harlan Saing, Yazid Dimyati, Cynthea Prima Destariani

Abstract :

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal"><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Background: </span></b><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Memory impairment is a negative impact that often occurs in childhood epilepsy patients. Memory impairment affects cognitive function and reduce th</span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-ansi-language:EN-GB">eir</span><span lang="IN" style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> quality of life. The incidence of memory impairment is ranging from 20 to 50% of childhood epilepsy. </span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-ansi-language:EN-GB">Polytherapy is a factor</span><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> may affect memory impairment in childhood epilepsy</span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:&#10;EN-GB"> patients</span><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">. <o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal"><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Objective: </span></b><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">To </span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-ansi-language:EN-GB">know relationship between polytherapyand</span><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> memory impairment in childhood epilepsy</span><span lang="EN-GB" style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-GB"> patients</span><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">.<b style="mso-bidi-font-weight:normal"><o:p></o:p></b></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal"><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Methods:</span></b><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">A cross sectional study </span><span lang="EN-GB" style="font-size:12.0pt;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-GB">was </span><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">performed in outpatient pediatric neurology division at Haji Adam Malik tertiary hospital Medanbetween October until November 2017. Characteristics and </span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:&#10;EN-GB">therapy</span><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> of epilepsy were obtained from parents interviewed</span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:&#10;EN-GB"> and medical records</span><span lang="IN" style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">. Epilepsy were diagnosed from clinical symptoms and electroencephalogram test. Memory test was performed with multiple subtests of Wechsler Intellegence Scale for Children-IV. <o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal"><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Results:</span></b><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">There </span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-ansi-language:EN-GB">were6</span><span lang="IN" style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> children (</span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:&#10;EN-GB">85.7</span><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">%)</span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-ansi-language:EN-GB"> from 7 children with polytherapy</span><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">who had memory impairment, where all of them have interference at the examination of concentration subtest. The </span><span lang="EN-GB" style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-GB">polytherapyhas a relationship to</span><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> the memory impairment in childhood epilepsy with PR= </span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:&#10;EN-GB">3</span><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">.</span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-ansi-language:EN-GB">995</span><span lang="IN" style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> (<i style="mso-bidi-font-style:normal">p</i>= 0.0</span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-ansi-language:EN-GB">32</span><span lang="IN" style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">). <o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal"><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Conclusion:</span></b><span lang="IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> This study showed that the </span><span lang="EN-GB" style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-GB">polytherapyhas a relationship to the</span><span lang="IN" style="font-size:12.0pt;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;"> memory impairment in childhood epilepsy</span><span lang="EN-GB" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-ansi-language:EN-GB"> patients</span><span lang="IN" style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">. <o:p></o:p></span></p>