Volume : 7, Issue : 10, October - 2018

COMPARISION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION WITH GABAPENTIN

Dr. S. V. Uma Devi, Dr S. Venugopal

Abstract :

Laryngoscopy and Intubation provoke cardiovascular responses that include hypertension, Tachycardia, Dysarrhythmias leading to myocardial ischemia and Heart failure. Objective:  This  randomized,  double-blind  study  was  conducted  to  evaluate  the  effect  of  gabapentin pretreatment  on  the  hemodynamic  response  to  laryngoscopy  and  endotracheal  intubation. Material and Methods:  A total of 60 cases aged 18-65 years, undergoing elective surgery under  general  anesthesia  with  endotracheal  intubation,  were  randomly  allocated  into  two  groups(Gabapentin and Placebo). Gabapentin group (30 cases) patients received Oral Gabapentin capsules 3 times i.e., at 18:00hrs and 24:00hrs (night before surgery) and 06:00hrs (on the morning of surgery). Placebo group (30cases) received oral Placebo capsules at the same timings as that of Gabapentin group. Anesthesia was induced with midazolam, glycopyrrolate, propofol, rumefentanyl and succinyl choline with preoxygenatio. Patients‘ heart rate (HR), systolic blood pressure (SBP), Diastolic blood pressure (DBP) and electrocardiography (ECG) changes were recorded  prior  to induction,  after induction,  and  at  0  minutes, 1  minute,  3  minutes,  5  minutes,  and  10 minutes   after   intubation.   Results:  The Heart Rate showed difference at all time intervals between the 2 groups. However this difference between the 2 groups was statistically significant only at the time of post induction.  SBP showed difference at all time intervals between the 2 groups which were statiscally significant only at the time of Zero minute. DBP showed difference at all time intervals between the 2 groups which were statistically significant at the time of Zero minute. The mean arterial pressure (MAP) showed difference at all time intervals between the 2 groups which were statiscally signiﬁcant at the time of Zero minute. Conclusion:  Gabapentin given as premedicant in three divided doses before surgery attenuated the pressor response to laryngoscopy and intubation in patients undergoing elective non-cardiac surgeries.

Keywords :

Laryngoscopy Endotracheal intubation Gabapentin

Article:

Download PDF Journal DOI : 10.15373/2249555X

Cite This Article:

Dr.S.V.Uma Devi, Dr S. Venugopal, COMPARISION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION WITH GABAPENTIN, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-7 | Issue-10 | October-2018