Volume : 7, Issue : 9, September - 2018

ASSOCIATION BETWEEN SERUM TESTOSTERONE AND FASTING BLOOD SUGAR IN ADULT MEN IN A TERTIARY CARE CENTRE

Dr. Sricharan. K. N, Dr. Alaka. K. S

Abstract :

<p class="MsoNormal" style="line-height:150%"><b style="mso-bidi-font-weight:&#10;normal"><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:Calii;position:relative;&#10;top:-3.0pt;mso-text-raise:3.0pt;letter-spacing:1.0pt">Introduction: </span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:Calii;position:relative;top:-3.0pt;mso-text-raise:&#10;3.0pt;letter-spacing:1.0pt">Type 2 Diabetes mellitus is the major cause of morbidity worldwide..It is also a major component of metabolic syndrome.Testosterone has a key role in insulin sensitivity and metabolism of lipids and cholesterol in adult men. Association between testosterone and all components of metabolic syndrome is not well studied in Indian adult men.Hence we conducted a study to look for the association with FBS.</span><span style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:Calii;position:relative;top:-3.0pt;mso-text-raise:&#10;3.0pt;letter-spacing:1.0pt;mso-ansi-language:EN-US;mso-bidi-font-weight:bold"><span style="mso-spacerun:yes">&nbsp;</span>Testosterone replacement along with other mainstay treatment for diabetes might improve the quality of life in those patients and hence decrease the burden of cardiovascular diseases.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:&#10;150%;mso-layout-grid-align:none;text-autospace:none"><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:Calii;position:relative;top:-3.0pt;mso-text-raise:&#10;3.0pt;letter-spacing:1.0pt"><o:p>&nbsp;</o:p></span></p> <p class="MsoNormal" style="margin-top:6.0pt;line-height:200%"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;Calii;position:relative;top:-3.0pt;mso-text-raise:3.0pt;letter-spacing:1.0pt">Material and Methods:</span></b><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:Calii;&#10;position:relative;top:-3.0pt;mso-text-raise:3.0pt;letter-spacing:1.0pt;&#10;mso-ansi-language:EN-US">This study was conducted as a cross sectional study, wherein written informed consent was taken prior to the investigation after detailed information given to the participants regarding the study on </span><span lang="EN-SG" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:Calii;position:relative;top:-3.0pt;mso-text-raise:&#10;3.0pt;letter-spacing:1.0pt;mso-ansi-language:EN-SG">patients aged more than 40 years admitted in A. J. Hospital and </span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;Calii;position:relative;top:-3.0pt;mso-text-raise:3.0pt;letter-spacing:1.0pt;&#10;mso-ansi-language:EN-US">predefined inclusion and exclusion criteria initiated after obtaining clearance from the institutions ethical committee. Testosterone level estimation done by Fluorescence Polarizing Immunoassay. The data was collected in pre-prepared Proforma and then transferred to a master chart for analysis. The collected data was analyzed using student&rsquo;s T test and Chi-Square Test.Statistical Analysis was done using SPSS software version 23.0. A &lsquo;p&rsquo; value less than 0.05(p&lt;0.05) is considered significant.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-top:6.0pt;line-height:200%"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:Calii;&#10;position:relative;top:-3.0pt;mso-text-raise:3.0pt;letter-spacing:1.0pt;&#10;mso-ansi-language:EN-US">Results: </span></b><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;Calii;position:relative;top:-3.0pt;mso-text-raise:3.0pt;letter-spacing:1.0pt;&#10;mso-ansi-language:EN-US">In the study conducted on 60 patients aged more than 40, admitted in A. J. Hospital we found that patients with higher FBS had low testosterone levels. After application of statistical analysis using students T test it was found that FBS was inversely related to testosterone level.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-top:6.0pt;line-height:200%"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:Calii;&#10;position:relative;top:-3.0pt;mso-text-raise:3.0pt;letter-spacing:1.0pt;&#10;mso-ansi-language:EN-US">Conclusion: </span></b><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;Calii;position:relative;top:-3.0pt;mso-text-raise:3.0pt;letter-spacing:1.0pt;&#10;mso-ansi-language:EN-US">In our study we intended to study the association between testosterone and metabolic syndrome, we observed that FBS was inversely correlated with testosterone.We conclude that low testosterone levels in adult men would be an indicator of impending insulin resistance.<o:p></o:p></span></p>