Volume : 7, Issue : 10, October - 2018

Study of Clinical Profile of Patients of Non Alcoholic Fatty Liver Disease and its Association with Metabolic Syndrome

Dr. Nithesh Kumar A, Prof. Dr. Noorul Ameen

Abstract :

<p class="paragraph" style="margin-top:11.25pt;margin-right:0in;margin-bottom:&#10;0in;margin-left:0in;margin-bottom:.0001pt;text-align:justify;line-height:13.5pt;&#10;background:white"><strong><span lang="EN-IN" style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Background :</span></strong><span lang="EN-IN" style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">&nbsp;Non-alcoholic fatty liver disease (NAFLD) is considered as the commonest liver problem in the western world and is increasingly being recognised as a major cause of liver-related morbidity and mortality. It is known to be associated with various metabolic abnormalities, but not much information is known regarding association between the metabolic disease and the severity of fatty liver .<o:p></o:p></span></p> <p class="paragraph" style="margin-top:11.25pt;margin-right:0in;margin-bottom:&#10;0in;margin-left:0in;margin-bottom:.0001pt;text-align:justify;line-height:13.5pt;&#10;background:white"><strong><span lang="EN-IN" style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Aims :&nbsp;</span></strong><span lang="EN-IN" style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">To study the clinical profile of patients of NAFLD as diagnosed by ultrasonography and to study the correlation between the non-alcoholic fatty liver disease and metabolic syndrome along with its individual components.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-top:11.25pt;text-align:justify;line-height:&#10;13.5pt;background:white"><strong><span lang="EN-IN" style="font-size:12.0pt;&#10;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Material and Methods :&nbsp;</span></strong><span lang="EN-IN" style="font-size:12.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">The study was an observational<span style="mso-spacerun:yes">&nbsp; </span>study of patients diagnosed as NAFLD, attending OPD and indoor patients of the Department of Medicine, </span><span lang="EN-IN" style="font-size:14.0pt;mso-ascii-font-family:&#10;Calii;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:&quot;Times New Roman&quot;;&#10;mso-hansi-font-family:Calii;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:&#10;Calii;mso-bidi-theme-font:minor-latin">, SREE BALAJI MEDICAL<span style="mso-spacerun:yes">&nbsp; </span>COLLEGE AND HOSPITAL , CHENNAI</span><span lang="EN-IN" style="font-size:12.0pt;font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">. All patients diagnosed with NAFLD were investigated for metabolic syndrome according to the NCEP ATP 3 Criteria and a relationship between NAFLD and metabolic syndrome was studied.</span><span lang="EN-IN" style="font-size:14.0pt;&#10;mso-ascii-font-family:Calii;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;;mso-hansi-font-family:Calii;mso-hansi-theme-font:minor-latin;&#10;mso-bidi-font-family:Calii;mso-bidi-theme-font:minor-latin"><o:p></o:p></span></p> <p class="paragraph" style="margin-top:11.25pt;margin-right:0in;margin-bottom:&#10;0in;margin-left:0in;margin-bottom:.0001pt;text-align:justify;line-height:13.5pt;&#10;background:white"><strong><span lang="EN-IN" style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;&#10;color:black;mso-themecolor:text1">Results :&nbsp;</span></strong><span lang="EN-IN" style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;;color:black;mso-themecolor:&#10;text1">51.4% of patients of NAFLD had metabolic syndrome and statistical significance was found with AST, diabetes mellitus and lipid profile.< /> <b style="mso-bidi-font-weight:normal">Conclusions</b> :<span style="mso-spacerun:yes">&nbsp; </span>Higher prevalence of all<span style="mso-spacerun:yes">&nbsp; </span>components of metabolic syndrome in cases of NAFLD.<span style="mso-spacerun:yes">&nbsp; </span>Early detection can help in modifying the disease course, delaying complications.<o:p></o:p></span></p>