Volume : 7, Issue : 10, October - 2018

A Study of Plasma Nesfatin-1 in obese and non obese in relation to Type 2 Diabetes Mellitus

Dr V Y Bhargav, Dr E Dhandapani

Abstract :

<p class="MsoNormal" style="text-align:justify;line-height:normal"><span lang="EN-IN" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">The prevalence of metabolic disease is reaching pandemicproportions worldwide, of which obesity and diabetes are the primarydiseases of concern. In major cases of diabetes and obesity, the defects lie in glucose metabolism and energy homeostasis. <o:p></o:p></span></p> <p class="MsoBodyText" style="line-height:200%"><b><span style="font-size:12.0pt;&#10;line-height:200%">AIMS AND OBJECTIVES:<o:p></o:p></span></b></p> <p class="MsoListParagraphCxSpFirst" style="text-align:justify;text-indent:-.25in;&#10;line-height:200%;mso-list:l0 level1 lfo1"><!--[if !supportLists]--><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;"><span style="mso-list:Ignore">a)<span style="font:7.0pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Estimation and comparison of Plasma Nesfatin-1 in patients with Obesity and DM<span style="mso-spacerun:yes">&nbsp; </span>with Normal individuals<o:p></o:p></span></p> <p class="MsoListParagraphCxSpMiddle" style="text-align:justify;text-indent:-.25in;&#10;line-height:200%;mso-list:l0 level1 lfo1"><!--[if !supportLists]--><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;"><span style="mso-list:Ignore">b)<span style="font:7.0pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Estimation and comparison of plasma Nesfatin-1 levels in Obese and Non-obese individuals.<o:p></o:p></span></p> <p class="MsoListParagraphCxSpLast" style="text-align:justify;text-indent:-.25in;&#10;line-height:200%;mso-list:l0 level1 lfo1"><!--[if !supportLists]--><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;"><span style="mso-list:Ignore">c)<span style="font:7.0pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Estimation and comparison of plasma Nesfatin-1 levels in Diabetic and Normal individuals<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b style="mso-bidi-font-weight:normal"><u><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">METHODS:<o:p></o:p></span></u></b></p> <p class="MsoNormal" style="text-align:justify;text-indent:.5in;line-height:200%"><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">It is a hospital based prospective study of 80 patients, which is conducted at SREE BALAJI MEDICAL COLLEGE. The material for study is formed by adult patients admitted to General wards in our hospital between October 2017 to August 2018fulfilling the inclusion and exclusion criteria.<b style="mso-bidi-font-weight:normal"><u><o:p></o:p></u></b></span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b style="mso-bidi-font-weight:normal"><u><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;Calii">CONCLUSION:<o:p></o:p></span></u></b></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span lang="EN-IN" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">In summary, our study demonstrated a significant lower values of plasmanesfatin-1 in obese individuals when compared to normal individuals and higher values in type2 diabetic individuals when compared to normal individuals</span><b style="mso-bidi-font-weight:normal"><u><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;Calii"><o:p></o:p></span></u></b></p>