Volume : 7, Issue : 10, October - 2018

DIFFERENCES OF 25-HYDROXYVITAMIN D SERUM LEVEL BETWEEN LIVER CIRRHOSIS AND HEPATOCELLULAR CARCINOMA PATIENTS IN HAJI ADAM MALIK GENERAL HOSPITAL MEDAN

Handoko Halim, Ratna Akbari Ganie, Gontar Alamsyah Siregar

Abstract :

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify"><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:&#10;text1">Liver cirrhosis is the third largest cause of death after cardiovascular and cancer. HCC is a liver malignancy that requires early diagnosis. Biological effects of vitamin D include the effects of anti</span></b><b style="mso-bidi-font-weight:&#10;normal"><span lang="IN" style="font-size:10.0pt;line-height:115%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1;mso-ansi-language:&#10;IN">-</span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:&#10;10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;&#10;mso-themecolor:text1">proliferation, anti-angiogenesis, pro-differentiation, anti-inflammatory, pro</span></b><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1;mso-ansi-language:IN">-</span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1">apoptosis, and immunity regulation. Previous studies reported that chronic liver patients had low levels of 25-hydroxyvitamin D.</span></b><b style="mso-bidi-font-weight:&#10;normal"><span lang="IN" style="font-size:10.0pt;line-height:115%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1;mso-ansi-language:&#10;IN"> The a</span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1">im</span></b><b style="mso-bidi-font-weight:&#10;normal"><span lang="IN" style="font-size:10.0pt;line-height:115%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1;mso-ansi-language:&#10;IN"> of this study is t</span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1">o differ 25-hydroxyvitamin D serum level between liver cirrho</span></b><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1;mso-ansi-language:IN">sis</span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1"> and hepatocellular carcinoma patients. Cross-sectional study of 32 consecutive admitted patients in Haji Adam Malik General Hospital Medan from December 2017 to March 2018. Patients were classified as liver </span></b><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:10.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:&#10;text1;mso-ansi-language:IN">cirrhosis </span></b><b style="mso-bidi-font-weight:&#10;normal"><span style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1">and hepatocellular carcinoma patients. Full blood count, hemostasis and liver function test were done. AFP and 25-hydroxyvitamin were measured. Univariate analysis and bivariate were done with SPSS version 2</span></b><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1;mso-ansi-language:IN">4</span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1">. There was no significant difference </span></b><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1;mso-ansi-language:IN">between </span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1">25-hydroxyvitamin D serum level </span></b><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1;mso-ansi-language:IN">on</span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1"> liver cirrho</span></b><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1;mso-ansi-language:IN">sis</span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1"> and hepatocellular carcinoma patients(p = 0.052).<o:p></o:p></span></b></p>