Volume : 7, Issue : 11, November - 2018

A study of haematological malignancies in the North Indian population - based only on hematomorphology.

Dr Kshama Tiwari, Dr S R Mehdi, Dr Fariya Ali Siddiqui

Abstract :

<p>&nbsp;</p> <p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:12.0pt;line-height:107%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Introduction-</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:107%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> Hematological malignancies are rising global concern and as developing countries being bearer of much higher proportion of populationwith a not very strong socio-economic conditions are causing higher burden of disease on world health scenario.</span><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:14.0pt;line-height:107%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></b></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Aim</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">- To study the haematological malignancies at a tertiary health care centre Lucknow in India based on age, sex and the type of malignancy with further sub typing wherever possible.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Material &amp; method</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">-A total of 149 cases of haematological malignancies were worked up from the Haematology section, Department of Pathology, Era&rsquo;s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh between 2016 to 2018<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Result</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">-</span><span lang="EN-IN" style="font-size:12.0pt;line-height:150%">Out of </span><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">total 149 cases of haematological malignancies, males were more commonly affected than female swith a ratio of 1.2:1 The most common malignancy was leukemia 92%, followed by lymphomas 5%, MDS 2% and plasma cell dyscrasias 1%.Together myeloid leukemia 84.67% were more common than lymphoid leukemia 15.33% and chronic leukemias were more prevalent with a frequency of 62.04% than acute leukemias constituting only 37.96 % of total.</span><span lang="EN-IN" style="font-size:&#10;12.0pt;line-height:150%"><o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;line-height:150%"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Conclusion</span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">-The commonest haematological malignancy in our study was leukemia, myeloid leukemias were more common than lymphoid; in myeloid CML constituted the substantial proportion of malignancies. Other diagnoses were lymphomas, plasma cell dyscrasias and myelodysplastic syndromes.<o:p></o:p></span></p>