Volume : 7, Issue : 11, November - 2018

A CLINICAL COMPARATIVE STUDY OF TWO INTUBATING DOSES OF CIS-ATRACURIUM DURING GENERAL ANAESTHESIA FOR RENAL TRANSPLANT SURGERIES.

Dr. Akruti Modi, Dr. Brijal N. Patel

Abstract :

<p>&nbsp;<b><span lang="EN-IN" style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Introduction</span></b><span lang="EN-IN" style="font-size: 14pt; font-family: &quot;Times New Roman&quot;, serif;">: Cisatracurium unlike atracurium is devoid of histamine-induced cardiovascular effects and this alone would be the greatest advantage in replacing atracurium for the facilitation of tracheal intubation. On the other hand, 2xED₉₅dose of cisatracurium (100micro/kg) do not yield satisfactory intubating conditions such as those seen with equipotent doses atracurium and therefore there commended intubating dose of cisatracurium is 3xED₉₅ . To understand better, we evaluated intubating condition with diferent doses of cisatracurium in renal transplant surgery.</span></p> <p class="MsoNormal"><b><span lang="EN-IN" style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Aims &amp; objectives</span></b><span lang="EN-IN" style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">: To evaluate and compare the intubating condition, duration of action, hemodynamic effects for different doses of cisatracurium.<o:p></o:p></span></p> <p class="MsoNormal"><b><span lang="EN-IN" style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Material &amp; methods</span></b><span lang="EN-IN" style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">: After informed patient&rsquo;s consent 60 patients in age group of 20-50 years were selected and included in the study. Patients were divided in two groups of 30 each, GROUP-A received intravenously 2&times;ED₉₅ (0.1mg/kg) dose of cisatracurium and GROUP-B received intravenously 3&times;ED₉₅(0.15mg/kg) during induction.<o:p></o:p></span></p> <p><span lang="EN-IN" style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-fareast-theme-font:minor-fareast;&#10;mso-ansi-language:EN-IN;mso-fareast-language:EN-GB;mso-bidi-language:AR-SA">&nbsp;<b>Results </b>:Better intubating condition,hemodynamic stability and longer duration of action was found with 0.15mg/kgdose of Cisatracurium than 0.1mg/kg Cisatracurium in a induction&nbsp;</span></p>