Volume : 7, Issue : 11, November - 2018

Mean platelet volume (MPV) in Non-Alcoholic fatty liver disease (NAFLD) patients

Nallathambi N, Sivakumar K, Jibin Joshua, K. Ambedkar Raj, Thamarai R

Abstract :

<p>&nbsp;<b style="text-align: justify;"><span lang="EN-IN" style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Introduction</span></b></p> <p class="MsoNormalCxSpMiddle" style="margin-bottom: 0.0001pt; text-align: justify; line-height: 200%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Increased&nbsp;mean platelet volume&nbsp;(MPV), a marker of platelet activity. There is a strong correlation between increased MPV and NAFLD patients.<o:p></o:p></span></p> <p class="MsoNormalCxSpMiddle" style="margin-bottom: 0.0001pt; text-align: justify; line-height: 200%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><b><span lang="EN-IN" style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Objectives</span></b><span lang="EN-IN" style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;"><o:p></o:p></span></p> <p class="MsoNormalCxSpMiddle" style="margin-bottom: 0.0001pt; text-align: justify; line-height: 200%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">The objectives of this study were to assess the mean platelet volume in patients with NAFLD, and to compare the MPV of patients with NAFLD and of the individuals without fatty liver. &nbsp;</span><span lang="EN-IN" style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;"><o:p></o:p></span></p> <p class="MsoNormalCxSpMiddle" style="margin-bottom: 0.0001pt; text-align: justify; line-height: 200%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><b><span lang="EN-IN" style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Materials and Methods<o:p></o:p></span></b></p> <p class="MsoNormalCxSpMiddle" style="margin-bottom: 0.0001pt; text-align: justify; line-height: 200%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span lang="EN-IN" style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Fifty NAFLD male patients and 50 age matched individuals without fatty liver were involved in this study as cases and controls respectively. Complete blood count was done in those patients to assess the MPV. Ultrasound Abdomen was done to diagnose NAFLD. </span><span lang="EN-IN" style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">All analyses were performed using SPSS software version 21. </span><b><i><span lang="EN-IN" style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;"><o:p></o:p></span></i></b></p> <p class="MsoNormalCxSpMiddle" style="margin-bottom: 0.0001pt; text-align: justify; line-height: 200%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><b><span lang="EN-IN" style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Results<o:p></o:p></span></b></p> <p class="MsoNormalCxSpMiddle" style="margin-bottom: 0.0001pt; text-align: justify; line-height: 200%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span lang="EN-IN" style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">The mean age of cases and controls was 47.8 &plusmn; 4.5 and 46.3 &plusmn; 3.8 respectively. MPV was significantly higher in NAFLD than non-fatty liver disease group (p = 0.01). <o:p></o:p></span></p> <p class="MsoNormalCxSpMiddle" style="margin-bottom: 0.0001pt; text-align: justify; line-height: 200%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><b><span lang="EN-IN" style="font-size: 12pt; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;">Conclusion<o:p></o:p></span></b></p> <p><span lang="EN-IN" style="font-size: 12pt; line-height: 107%; font-family: &quot;Times New Roman&quot;, serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">MPV strongly correlates with NAFLD patients. Increased MPV indicates enhanced platelet activity and this may be used as a simple surrogate marker for the prediction of NAFLD.&nbsp;</span></p>