Volume : 7, Issue : 12, December - 2018

A Study of Hepatitis A and Hepatitis E virus in clinically suspected cases of Acute Viral Hepatitis at A Tertiary Care Hospital.

Dr. Jayshri Pethani, Dr. Hitarthi Mehta, Dr. Komal Dholaria, Dr. Atit Shah, Dr. Bimal Chauhan, Dr. Lata Patel

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:0in;margin-bottom:&#10;.0001pt;line-height:110%"><b><span lang="EN-IN" style="font-size:14.0pt;&#10;line-height:110%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;;mso-fareast-language:EN-IN">Introduction</span></b><span lang="EN-IN" style="font-size:14.0pt;line-height:110%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-fareast-language:EN-IN">: Hepatitis A virus(HAV) and Hepatitis E virus(HEV) are both enterically transmitted, resulting in acute viral hepatitis(AVH) in developing countries. <o:p></o:p></span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:0in;margin-bottom:&#10;.0001pt;line-height:110%"><b><span lang="EN-IN" style="font-size:14.0pt;&#10;line-height:110%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;;mso-fareast-language:EN-IN">Methods</span></b><span lang="EN-IN" style="font-size:14.0pt;line-height:110%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-fareast-language:EN-IN">: This study was done a record based at tertiary care hospital, Ahmedabad from January 2016 to December 2016 for the detection of HAV and HEV, using commercially available ELISA kits.<o:p></o:p></span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:0in;margin-bottom:&#10;.0001pt;line-height:110%"><b><span lang="EN-IN" style="font-size:14.0pt;&#10;line-height:110%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;;mso-fareast-language:EN-IN">Results</span></b><span lang="EN-IN" style="font-size:14.0pt;line-height:110%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-fareast-language:EN-IN">: Out of 1325 samples, 342 were positive for HAV, indicating a prevalence rate of 25.8%, majority patients were in the paediatric age group 1-10 years. In the case of HEV, 796 samples were positive indicating prevalence rate of 60%, majority patients were in adult age group 20-30 years. The seroprevalence of both HAV and HEV in patients with acute viral hepatitis was 4.22%, with 53.5% were males and 46.4% females.<o:p></o:p></span></p> <p class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:0in;margin-bottom:&#10;.0001pt;line-height:110%"><b><span lang="EN-IN" style="font-size:14.0pt;&#10;line-height:110%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;;mso-fareast-language:EN-IN">Conclusion</span></b><span lang="EN-IN" style="font-size:14.0pt;line-height:110%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-fareast-language:EN-IN">: This study shows a high prevalence of HEV than HAV. Prevalence was higher in adult and paediatric age group in case of HEV and HAV respectively and their co-infection rate was 4.22%.<o:p></o:p></span></p>