Volume : 7, Issue : 12, December - 2018
A DURATION BASED COMPARATIVE STUDY TO CORRELATE hsCRP WITH MICROALBUMINURIA AMONG DIABETIC OUTPATIENTS ATTENDING A TERTIARY CARE HOSPITAL IN SUBHIMALAYAN REGION.
Dona Acharjya, Swati Bhattacharyya, Ushasi Banerjee
Abstract :
<p> <b style="text-align: justify;"><span style="font-family:"Times New Roman","serif"; color:windowtext">Background</span></b><span style="text-align: justify; font-family: "Times New Roman", serif; color: windowtext;">: Microalbuminuria in type 2 diabetic patients is speculated to be accompanied by elevated serum high sensitivity C reactive protein (hsCRP). . Establishing a correlation between hsCRP & microalbuminuria relative to duration of diabetes suggests activation of inflammatory pathways in progression of kidney disease .</span></p> <p class="MsoNormal" style="line-height:150%"><b><span style="font-size:12.0pt;line-height:150%;font-family:"Times New Roman","serif"">Materials &Methods:</span></b><span style="font-size:12.0pt;line-height:150%; font-family:"Times New Roman","serif""> 120 diabetic individuals aged (30-60) yrs ,divided in 3 groups of 40 subjects in each, namely: a) newly diagnosed˂5 years b) 5-10 years after diagnosis and c) ≥10 years after diagnosis were recruited from a tertiary care hospital in sub Himalayan region according to some inclusion and exclusion criteria.<b><o:p></o:p></b></span></p> <p class="Default" style="text-align:justify;line-height:150%"><b><span style="font-family:"Times New Roman","serif"; color:windowtext">Result: </span></b><span style="font-family:"Times New Roman","serif"; color:windowtext">Mean values of hsCRP were 0.04 ± 0.005, 0.08 ± 0.011, & 0.10 ± 0.017 and that of micro albumin were 95.42 ± 12.30, 116.79 ± 4.87 & 130.56 ± 7.65 in group 1,2 ,3 respectively. One way ANOVA with post hoc analysis after Bonferroni correction depicted that both hsCRP & micro albumin increased significantly and statistically with duration of diabetes in all 3 groups along with a very significant correlation between them .<o:p></o:p></span></p> <p><b><span style="font-size:11.0pt; line-height:115%;font-family:"Times New Roman","serif";mso-fareast-font-family: Calii;mso-fareast-theme-font:minor-latin;mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">Conclusion:</span></b><span style="font-size: 11.0pt;line-height:115%;font-family:"Times New Roman","serif";mso-fareast-font-family: Calii;mso-fareast-theme-font:minor-latin;mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">Both serum hsCRP and microalbuminuria increases with period of diabetes.So the increasing trend of these inflammatory markers needs to be noted early and monitored to prevent progression of diabetic nephropathy</span></p>
Keywords :
Cite This Article:
A DURATION BASED COMPARATIVE STUDY TO CORRELATE hsCRP WITH MICROALBUMINURIA AMONG DIABETIC OUTPATIENTS ATTENDING A TERTIARY CARE HOSPITAL IN SUBHIMALAYAN REGION. , Dona Acharjya, Swati Bhattacharyya, Ushasi Banerjee , GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-7| Issue-12 | December-2018