Volume : 7, Issue : 12, December - 2018

A DURATION BASED COMPARATIVE STUDY TO CORRELATE hsCRP WITH MICROALBUMINURIA AMONG DIABETIC OUTPATIENTS ATTENDING A TERTIARY CARE HOSPITAL IN SUBHIMALAYAN REGION.

Dona Acharjya, Swati Bhattacharyya, Ushasi Banerjee

Abstract :

<p>&nbsp;<b style="text-align: justify;"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:windowtext">Background</span></b><span style="text-align: justify; font-family: &quot;Times New Roman&quot;, serif; color: windowtext;">: Microalbuminuria in type 2 diabetic patients is speculated to be accompanied by elevated serum high sensitivity C reactive protein (hsCRP). . Establishing a correlation between hsCRP &amp; microalbuminuria relative to duration of diabetes suggests activation of inflammatory pathways in progression of kidney disease .</span></p> <p class="MsoNormal" style="line-height:150%"><b><span style="font-size:12.0pt;line-height:150%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Materials &amp;Methods:</span></b><span style="font-size:12.0pt;line-height:150%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> 120 diabetic individuals aged (30-60) yrs ,divided in 3 groups of 40 subjects in each, namely:&nbsp; a) newly diagnosed˂5 years b) 5-10 years after diagnosis and c) &ge;10 years after diagnosis were recruited from a tertiary care hospital in sub Himalayan region according to some inclusion and exclusion criteria.<b><o:p></o:p></b></span></p> <p class="Default" style="text-align:justify;line-height:150%"><b><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:windowtext">Result: </span></b><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:windowtext">Mean values of hsCRP were 0.04 &plusmn; 0.005, 0.08 &plusmn; 0.011, &amp; 0.10 &plusmn; 0.017 and that of micro albumin were 95.42 &plusmn; 12.30, 116.79 &plusmn; 4.87 &amp; 130.56 &plusmn; 7.65 in group 1,2 ,3 respectively. One way ANOVA with post hoc analysis after Bonferroni correction depicted that both hsCRP &amp; micro albumin increased significantly and statistically with duration of diabetes in all 3 groups along with a very significant correlation between them .<o:p></o:p></span></p> <p><b><span style="font-size:11.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;Calii;mso-fareast-theme-font:minor-latin;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA">Conclusion:</span></b><span style="font-size:&#10;11.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;Calii;mso-fareast-theme-font:minor-latin;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA">Both serum hsCRP and microalbuminuria increases with period of diabetes.So the increasing trend of these inflammatory markers needs to be noted early and monitored to prevent progression of diabetic nephropathy</span></p>