Volume : 7, Issue : 12, December - 2018

The Effect of Mucin-1, Glycodelin-a, Leukemia Inhibitory Factor, Interleukin-15 and Granulocyte Colony Stimulation Factor in the Unexplained Recurrent Pregnancy Loss - A Case Control Study

Murat Polat, Nadi Keskin, Ghanim Khatib

Abstract :

<p class="MsoNormal" style="margin-top:24.0pt;margin-right:0in;margin-bottom:
0in;margin-left:0in;margin-bottom:.0001pt;text-align:justify;line-height:normal;
mso-pagination:widow-orphan lines-together;page-eak-after:avoid;mso-outline-level:
1">Purpose: To examine the effect on recurrent pregnancy loss of Mucın-1, Glycodelin-a, Leukemia Inhibitory Factor, Interleukin-15 and Granulocyte Colony Stimulation Factor blood serum levels and for those with the greatest effect to be able to contribute to alternative treatment approaches.<o:p></o:p> Materials and Methods: The study was conducted between November 2016 and December 2016 in the Obstetrics and Gynaecology Clinic of Evliya Celebi Training and Research Hospital, Dumlupinar University Medical Faculty. A total of 87 patients were included, comprising 42 patients who had experienced at least 2 consecutive pregnancy losses before the 12th week, and a control group of 45 patients with at least 1 live birth and no pregnancy loss. Examination was made of the blood plasma levels of Mucın-1, Glycodelin-a, Leukemia Inhibitory Factor, Interleukin-15 and Granulocyte Colony Stimulation Factor. <o:p></o:p> Results: In the patient and control groups the Mucin-1 plasma levels were determined as 0.88±0.45 ng/ml and 1.17±0.57 ng/ml (p=0.008) respectively, Glycodelin-a as 23.73 ng/ml and 25,92 ng/ml (p=0.006). Leukemia Inhibitory Factor as 64.59 pg/mL, and 72.14 pg/mL (p=0,011), Interleukin-15 as 38.57 ng/ml and 31.44 ng/ml (p=0.013), and Granulocyte Colony Stimulation Factor as 13.07 pg/mL and 14.11 pg/mL (p=0.056).<o:p></o:p> Conclusion: According to the results of this study, Mucın-1, Glycodelin-a, Leukemia Inhibitory Factor, and Interleukin-15 play an imprtant role in the pathology of RPL. Further studies conducted on these factors could be successful in the treatment of RPL. <o:p></o:p>

Keywords :

Recurrent pregnancy loss Mucin-1 Glycodelin-a Leukemia Inhibitory Factor Interleukin-15 Granulocyte Colony Stimulation Factor

Article:

Download PDF Journal DOI : 10.15373/2249555X

Cite This Article:

The Effect of Mucin-1, Glycodelin-a, Leukemia Inhibitory Factor, Interleukin-15 and Granulocyte Colony Stimulation Factor in the Unexplained Recurrent Pregnancy Loss‾A Case Control Study , Murat Polat, Nadi Keskin, Ghanim Khatib , GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-7| Issue-12 | December-2018