Volume : 8, Issue : 1, January - 2019

ANTIOXIDANT AND FREE RADICAL SCAVENGING EFFECT OF PRUCALOPRIDE : AN INVITRO STUDY

Sriram. S, Arul Amutha Elizabeth, Inbaraj. S. D

Abstract :

Introduction: Reactive oxygen species like superoxide radicals, hydroxyl radicals, singlet oxygen are implicated in causing tissue injury and cytotoxicity. They play a vital role in various diseases like ischaemic disease, degenerative disease and many more. Prucalopride is a novel drug used in chronic constipation that acts as selective, high affinity 5-HT4 receptor agonist which targets the impaired motility. This in-vitro study was done with an objective to evaluate additional radical scavenging property of the drug prucalopride. Materials and Methods: In-vitro DPPH assay and Nitric oxide scavenging assay. Results: The methanol extract of the drug Prucalopride showed free radical scavenging effect with DPPH at the concentration of 1000 µg/ml. And also an increase in nitric oxide scavenging effect was observed with increased concentration of drug.