Volume : 6, Issue : 2, February - 2017

Relationships between ?-glutamyltransferase and insulin resistance, glucose effectiveness, and first- and second-phase insulin secretion in young adults

Yi Lun Chiang, Jin Biou Chang, Dee Pei, Yen Lin Chen

Abstract :

<p>&nbsp;<span style="font-size: 12px; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Type 2 diabetes mellitus (T2DM) is more prevalent in young adults. T2DM affects insulin resistance (IR), glucose effectiveness (GE), and first- and second-phase insulin secretion (FPIS and SPIS, respectively). &upsih;-glutamyltransferase (&upsih;-GT), an inflammatory marker, is related to IR, but whether &upsih;-GT is related to FPIS, SPIS, or GE is unclear. We investigated the associations of &upsih;-GT with these four factors. We noted that&nbsp;&upsih;-GT positively correlates with IR, SPIS, and FPIS, and negatively correlates with GE in young population without diabetes (18-27 years, 23188 men and 29230 wom</span><span style="font-size: 12px; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">en). GE is most tightly related to &upsih;-GT (</span><i style="font-size: 12px;"><span style="mso-bidi-font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif">r</span></i><span style="font-size: 12px; line-height: 200%; font-family: &quot;Times New Roman&quot;, serif;"> = -0.375 for men, <i>r</i> =-0.176 for women<span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">). GE should not be overlooked in both sexes.</span></span></p> <p class="MsoNormal" style="line-height:200%"><span style="mso-bidi-font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,serif"><span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><o:p></o:p></span></span></p>