Volume : 6, Issue : 6, June - 2017

A STUDY OF ETIOLOGICAL, CLINICAL AND HEMATOLOGICAL CORRELATION IN PAEDIATRIC PATIENTS WITH PANCYTOPENIA/BICYTOPENIA.

Dr. Swati Singh, Dr. Vinay Kumar, Dr. Rajni Bharti

Abstract :

<p>&nbsp;&nbsp;Background:&nbsp;The etiology of bicytopenia/pancytopenia varies widely in paediatric patients, ranging from transient marrow viral suppression to marrow infiltration by fatal malignancy. Depending on the etiology, the clinical presentation can be with fever, pallor or infection. Knowing the exact etiology is important for specific treatment and prognosis. Aims: To study of etiological, clinical and hematological correlation&nbsp; in paediatric patients with pancytopenia/bicytopenia. Materials and Methods:&nbsp;A review of bicytopenic and pancytopenic children referred for bone marrow examination from December 2011 to October 2013 at S. N Medical college Agra &nbsp;was done. Detailed history, clinical examination and hematological parameters at presentation were recorded. Conclusion:&nbsp;During the study period, a total of 32 children were referred for bone marrow examination for different indications. Of these, 17(53%) had pancytopenia and 15 bicytopenia (47%). In patients with bicytopenia, Anemia and thrombocytopenia was the commonest combination (11 patients) followed by leucopenia and the thrombocytopenia and anemia and leucopenia (2 patients each). Among the children who presented with bicytopenia fever (93%), pallor (40%) generalized weakness (33%), bleeding (20%) were the commonest clinical findings. Fever (82%) was the commonest clinical finding in patients who presented with pancytopenia ,followed&nbsp;&nbsp;&nbsp; by pallor (64%) ,splenomegaly(41%) ,bleeding manifestations(29%) and hepatomegaly(29%).</p>