Volume : 6, Issue : 5, May - 2017

A CORRELATIVE STUDY OF SERUM GAMMA-GLUTAMYL TRANSPEPTIDASE WITH SERUM LIPID PROFILE IN YOUNG ADULT HYPERTENSIVE PATIENTS IN INDIAN POPULATION

Sarla Mahawar, Aaradhana Jatwa, Deepa Thadani, Gg Kaushik, Lal Thadani

Abstract :

<p>&nbsp;Background: &nbsp;Hypertension and dyslipidemia are major risk factors for cardiovascular disease (CVD) and account for more than 80% of deaths and disability in low and middle-income countries. Gamma-glutamyl transpeptidase is serum transferase enzyme synthesised by liver. GGT initially used as an indicator of alcohol ingestion is now viewed as a sensitive marker of sub clinical inflammation. Our study was aimed to find out the status of serum GGT and serum lipid profile in hypertensive and&nbsp; normo-tensive subjects &amp;&nbsp; correlation of&nbsp; serum&nbsp;&nbsp; GGT with serum&nbsp; lipid profile in&nbsp;&nbsp; hypertensive subjects. &nbsp;&nbsp;Materials and Methods: The present study was conducted on 100 patients &nbsp;&nbsp;with essential hypertension&nbsp;who attended the medical OPD of&nbsp; Jawahar Lal Nehru Medical College and Associated Group of Hospital, Ajmer. The results of patients were compared with 50 normotensive subjects. Anthropometric para- meters and biochemical estimation were performed after taking approval from Ethical Committee.&nbsp; The serum total cholesterol (TC),&nbsp; triglyceride (TG)&nbsp; and HDL cholesterol (HDL-C) were determined&nbsp; enzymatically, while&nbsp; LDL cholesterol (LDL-C) was calculated using the&nbsp; Friedewald formula &amp; serum GGT was measured by colorimetric kinetic assay. Results: The mean serum level of &nbsp;GGT was elevated in hypertensive subjects as compared to normotensive&nbsp; subjects (controls) and was &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;statistically significant (P&lt;0.001). The mean values of serum TC, TG and LDL-C&nbsp; were significantly higher and statistically significant among the hypertensive patients compared to normotensive subjects &amp; the mean HDL &ndash;C level was lower in the hypertensive subjects compared to normo- tensive subjects and was statistically significant. The present study has also shown the positive correlation between serum GGT and serum TC, TG and LDL-C &amp; negative correlation between serum GGT and HDL-C in hypertensive subjects.&nbsp;&nbsp; Conclusion: The&nbsp; observations&nbsp; of&nbsp; this study have revealed that there was significant alteration of serum GGT, cholesterol, triglyceride, HDL cholesterol and LDL cholesterol in hypertensive patients. GGT can be used a potent biochemical marker for preclinical development of atherosclerosis. Therefore, for routine monitoring of hypertensive patients to prevent the coronary heart disease (CHD) and other consequences, the reinforcement of these parameters may be recommended in daily clinical practice. This study was limited and this topic needs to be further worked upon.</p>