Volume : 6, Issue : 7, July - 2017

High maternal viral load key to vertical transmission of hepatitis B

Dr Shweta Mishra, Dr Manju Varma

Abstract :

<p>&nbsp;<b style="text-indent: 2.7pt;"><span style="font-size: 12pt; line-height: 97%;">Objectives: </span></b><span style="text-indent: 2.7pt;">To </span><b style="text-indent: 2.7pt;"><span style="font-size: 12pt; line-height: 97%;">&nbsp;</span></b><span style="text-indent: 2.7pt;">assess the risk of perinatal hepatitis B virus (HBV) transmission by quantitative HBV DNA.</span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:&#10;9.5pt;mso-line-height-rule:exactly;mso-pagination:none;mso-layout-grid-align:&#10;none;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="margin-top:0in;margin-right:8.0pt;margin-bottom:0in;&#10;margin-left:0in;margin-bottom:.0001pt;line-height:98%;mso-pagination:none;&#10;mso-layout-grid-align:none;punctuation-wrap:simple;text-autospace:none"><b><span style="font-size: 12pt; line-height: 98%;">Method</span></b><span style="font-size: 12pt; line-height: 98%;">:<b> </b></span>The present study was carried out at MLN Medical College Allahabad a total of 5000 pregnant patients<b><span style="font-size: 12pt; line-height: 98%;"> </span></b>were screened for HBV infection. HBsAg positive women were enrolled for the study. Infectivity status was determined by HBeAg positivity by Elisa and quantitative HBV DNA by RT PCR. At the time of delivery cord blood was taken to assess the perinatal transmission.<span style="font-size:12.0pt;line-height:98%;&#10;font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:&#10;9.7pt;mso-line-height-rule:exactly;mso-pagination:none;mso-layout-grid-align:&#10;none;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,serif">&nbsp;</span></p> <p class="MsoNormal" style="margin-top:0in;margin-right:12.0pt;margin-bottom:&#10;0in;margin-left:0in;margin-bottom:.0001pt;line-height:98%;mso-pagination:none;&#10;mso-layout-grid-align:none;punctuation-wrap:simple;text-autospace:none"><b><span style="font-size: 12pt; line-height: 98%;">Result: </span></b>. Total vertical transmission was 37.5% .In all<b><span style="font-size: 12pt; line-height: 98%;"> </span></b>HBeAg positive mother 63.63% showed vertical transmission. In HBsAg positive women with High viral Load (&gt;1x10⁵ copies/ml)showed 90% vertical transmission. Thus vertical transmission depends upon the HBV viremia levels.<span style="font-size:12.0pt;line-height:98%;font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p>