Volume : 6, Issue : 7, July - 2017

OVER EXPRESSION OF HPV E6/E7 ONCOPROTEINS IS A MARKER OF PROGRESSION TO CERVICAL CANCER

Dr. T. G. Revathy, Dr. D. Kamali

Abstract :

<p>&nbsp;AIM:- &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; For early detection and treatment of cancer cervix developing new molecular diagnosis method for screening and treating the patient on the E6 gene expression. &nbsp; SUBJECTS &amp; METHODS:- &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; STUDY DESIGN: &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Prospective Study &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; STUDY PERIOD: &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AUGUST 2015 to AUGUST 2016 &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PLACE OF STUDY: &nbsp;&nbsp;&nbsp; Department of Obstetrics &amp; gynaecology, &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Government Kasturba Gandhi Hospital, &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Triplicane, Chennai. &nbsp; METHODS:- &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Colposcopy guided blood material, mucus and inflammatory cells from cervix with help of plastic spatula and endocervical ush, this material into liquid fixative solution. The suspended cells are gently sucked on to filter memane and filter pressed onto glass slide to form thin monolayer. The liquid is employed to test HPV infection making it a cost effective technique.&nbsp;&nbsp;</p>