Volume : 6, Issue : 7, July - 2017

EFFECT OF SOLANUM NIGRUM ON LIPID METABOLISM IN DIABETIC RATS

B. Chithra, Dr. S. Sivajiganesan, Dr. S. Jasmine Mary

Abstract :

<p>&nbsp;<span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">Leaves of &ldquo;</span><b style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">Solanum nigrum</b><span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">&rdquo; are used as an important medicinal agent and the present work is about the studies of biological role of Solanum nigrum in diabetic rats.</span><span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">&nbsp; </span><span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">Diabetes was induced by treating the male albino rats with single subcutaneous injection of alloxan.</span><span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">&nbsp;&nbsp; </span><span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">But the mechanism has not yet to be understood.</span><span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">&nbsp; </span><span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">However, it is believed that alloxan specifically disrupt &beta; cell pancreas.</span><span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">&nbsp; </span><span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">The alcoholic extraction of leaves of solanum nigrum has been used to evaluate its effect against diabetes mellitus by analyzing various biochemical parameters such as SGOT, SGPT, Acid phosphatase, Alkaline Phosphatase, Lipid status etc., Interestingly after administration of Solanum nigrum to diabetic rats for a week, the values of SGOT, SGPT, Acid and Alkaline Phosphatase were reduced to reference values as in normal.</span><span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">&nbsp; </span><span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">The results presented in this research work clearly demonstrate that solanum nigrum has great potential against hyperglycemic effect.</span><span style="font-family: &quot;Times New Roman&quot;, serif; text-align: justify;">&nbsp;&nbsp;</span></p> <p class="MsoNormal" style="text-align:justify"><span style="font-family:&quot;Times New Roman&quot;,serif"><o:p></o:p></span></p>