Volume : 6, Issue : 7, July - 2017

A study of association between risk of airflow limitation and serum uric acid

Dr. Gaurav R. Dubey, Dr. Pranay Gandhi

Abstract :

<p>&nbsp;</p> <h1 style="text-align: justify; line-height: 200%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Arial&quot;,sans-serif;mso-fareast-font-family:&quot;Times New Roman&quot;;font-weight:normal;&#10;mso-bidi-font-weight:bold">The aims of this study were to examine the relationship between AL and s-UA and to investigate s-UA as a potential auxiliary marker for predicting AL risk in medical health check-ups. A total of 8,662 subjects aged &gt;40 years were included. They were administered a simple questionnaire and assessed using pulmonary function tests, blood pressure (BP) measurements, and blood samplings. One hundred and fifty-six subjects (1.8%) had AL, just 29% of whom had experienced respiratory symptoms. The subjects with AL had significantly higher s-UA levels compared with never-smoking subjects without AL. Forced expiratory volume in 1 second (FEV1) %predicted showed significant correlations with age, smoking index, body mass index (BMI), mean BP, white blood cells, hemoglobin A1c, s-UA, and high-density lipoprotein cholesterol. In multiple logistic regression analysis, s-UA, in addition to age, smoking index, respiratory symptoms, and BMI, was independently associated with AL. In conclusion, elevated s-UA levels, together with respiratory symptoms, high smoking index, and weight loss, may epidemiologically predict the development of AL risk.<o:p></o:p></span></h1>