Volume : 6, Issue : 7, July - 2017

A retrospective study of adverse drug reactions to highly active anti-retroviral therapy in an antiretroviral therapy centre attached to a government medical college and hospital of Maharashtra.

Dr Pravin S. Rathod, Rekha P. Lohar

Abstract :

<p>&nbsp;<span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">&nbsp;</span><b style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">Background</b><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">:</span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">&nbsp; </span><span style="font-family: &quot;Times New Roman&quot;, serif; font-size: 12pt;">Adverse drug reactions have been one of the most important limiting factors to the success of HAART. Hence, the present study was conducted to assess the incidence, causality and severity of ADRs to HAART, and to identify risk factors for ADRs in HIV-positive patients receiving ART in India.</span></p> <p class="MsoNormal"><b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,serif">Methods</span></b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,serif">:&nbsp; It was a retrospective observational study of six months duration, conducted in a tertiary care hospital attached to SBH Government Medical College, Dhule. A total of 109 Patients reported with ADRs to HAART during July 2015-December 2015 were randomly included in the study.<o:p></o:p></span></p> <p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&#10;&quot;Times New Roman&quot;,serif">&nbsp;<b>Results</b>: &nbsp;In the present study, Anaemia (76.52%), was the commonest ADR reported followed by skin rash (11.36%) and raised renal function test (6.06%). Out of 132 ADRs, 101 (76.52%) ADRs were belonging to haematological&nbsp;&nbsp; system. Zidovudine/Lamivudine/Nevirapine (ZLN) regimen ( 71.52%) use reported majority of ADRs. 120 (90.91%) ADRs were possible by Naranjo&rsquo;s causality assessment scale.<o:p></o:p></span></p> <p class="MsoNormal"><b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,serif">&nbsp;Conclusion</span></b><span style="font-size:&#10;12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,serif">: &nbsp;Anaemia was the commonly reported ADR from ART. , The findings of our study suggest that treating physicians must focus on early detection and prevention of ADRs in HIV infected patients of ART centers to improve the adherence to ART.<o:p></o:p></span></p>