Volume : 7, Issue : 3, March - 2018

A COMPARATIVE STUDY OF PROPOFOL-KETAMINE AND PROPOFOL-FENTANYL FOR TOTAL INTRAVENOUS ANAESTHESIA FOR SHORT SURGICAL CASES IN PAEDIATRIC PATIENTS

Dr Virendra Singh Raghuvanshi, Dr. Sasmita Panda

Abstract :

<p>&nbsp;</p> <p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Aims and objective</span></b><span style="font-size:12.0pt;line-height:115%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> :To compare combinations of <span style="mso-spacerun:yes">&nbsp;</span>Propofol-Ketamine and Propofol-Fentanyl for total intravenous anesthesia in short surgical cases in pediatric patients. The study also <span style="mso-spacerun:yes">&nbsp;</span>compared <span style="mso-spacerun:yes">&nbsp;</span>recovery characteristics and<span style="mso-spacerun:yes">&nbsp; </span>the incidence of side effects / complications in the groups.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt"><b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">Methodology:</span></b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> The patients were randomly divided into two groups depending upon the drug combination used for Total Intravenous Anaesthesia.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Group I : 30 patients were given i.v. Ketamine followed by Propofol.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;mso-layout-grid-align:none;text-autospace:&#10;none"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Group II: 30 patients were given i.v. Fentanyl followed by Propofol <o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;mso-layout-grid-align:none;text-autospace:&#10;none"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Recovery characteristics were compared<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp; </span>the incidence of side effects and complications in two groups were noted.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:7.5pt;background:white"><b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">Results:</span></b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">&nbsp;</span><span style="font-size:&#10;12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">The pulse rate<span style="mso-spacerun:yes">&nbsp; </span>and blood pressure remained near to preinduction value in group I, while in group II<span style="mso-spacerun:yes">&nbsp; </span>these values<span style="mso-spacerun:yes">&nbsp; </span>decreased. After induction RR increased in group I but decreased<span style="mso-spacerun:yes">&nbsp; </span>in group II at 1,3%5 min after induction.None of the patients in both groups were observed to have nausea, vomiting and respiratory depression. . A significant no. of the patients in group II were observed to have either pain on injection site or restlessness. <o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:7.5pt;text-align:justify;text-justify:&#10;inter-ideograph;background:white"><b><span style="font-size:12.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;">Conclusion:</span></b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> Propofol-Ketamine and Propofol-Fentanyl combinations provide satisfactory surgical conditions for minor surgical procedures in paediatric patients, but the Propofol-Ketamine combination gives better hemodynamic stability and less restlessness during induction and maintenance of anaesthesia.</span><b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">&nbsp;</span></b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;"><o:p></o:p></span></p>