Volume : 7, Issue : 8, August - 2018

DIRECT IMMUNOFLUORESCENCE PROFILE OF LICHEN PLANUS - A FRESH LOOK ON OLD DISEASE. A STUDY OF 15 CASES.

Dr Deeksha Singh, Dr Shilpi Agarwal, Dr Ram Chander, Dr Kiran Agarwal, Dr Preksha Singh

Abstract :

<p class="Body" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:justify;&#10;text-justify:inter-ideograph;line-height:200%;mso-hyphenate:none"><b><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1">Introduction</span></b><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1;mso-bidi-font-weight:bold">: Lichen planus </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1">(LP)<span style="mso-bidi-font-weight:bold"> is a chronic inflammatory mucocutaneous diasease that is often diagnosed on the basis of clinical &amp;/or histopathologic findings. However, it has some characteristic direct immunofluorescence (DIF) findings that can help in diagnosing confusing cases.<b>Aim:</b></span></span><span style="font-size:&#10;12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:windowtext;&#10;background:white">We analyzed </span><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1;&#10;mso-bidi-font-weight:bold">DIF</span><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:windowtext;background:white"> findings in skin biopsy in LP compared to histopathology. <b style="mso-bidi-font-weight:&#10;normal">Materials &amp; methods:</b> A skin biopsy of lesion was taken from 15 cases of LP(13 classic LP &amp; 2 LP pigmentosus) &amp; subjected to histopathology &amp; DIF examination. <b style="mso-bidi-font-weight:normal">Results:</b></span><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1">The sensitivity of histopathology and DIF was found to be 100% &amp; 93.3% respectivelyfor the diagnosis of LP &amp; LPP.</span><span lang="FR" style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1;mso-ansi-language:FR;mso-bidi-font-weight:&#10;bold"><o:p></o:p></span></p>