Volume : 7, Issue : 9, September - 2018
BIOAPIFIT ANTI-HEMORRHOIDAL OINTMENT EFFICIENCY - A COMPARISON WITH STANDARD APPROACH
Orescanin Visnja, Findri Gustek Stefica, Rodic Josipa
Abstract :
<p class="MsoHeader" style="text-align:justify;tab-stops:right 0in"><b><span style="font-size:10.0pt;mso-ansi-language:EN-US">Hemorrhoids are defined as varicosities of the veins of the hemorrhoidal plexus, often complicated by inflammation, pain, thrombosis, and bleeding. The objective of this study wasto assess </span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;mso-ansi-language:EN-US">the efficacy of new Bioapifit</span></b><b style="mso-bidi-font-weight:normal"><sup><span style="font-size:10.0pt; font-family:Symbol;mso-ascii-font-family:"Times New Roman";mso-hansi-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-char-type:symbol;mso-symbol-font-family: Symbol"><span style="mso-char-type:symbol;mso-symbol-font-family:Symbol">Ò</span></span></sup></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;mso-ansi-language: EN-US">multi-component ointment consisted of <span style="mso-bidi-font-weight: bold">honey, </span><i style="mso-bidi-font-style:normal">Cera flava, </i>glycerin,<span style="mso-bidi-font-weight:bold">the oil macerates of</span><i style="mso-bidi-font-style:normal"> Achilea millefolium</i> L.<i style="mso-bidi-font-style:normal">,<span style="mso-spacerun:yes"> </span>Plantago major</i> L.<i style="mso-bidi-font-style:normal">, <span style="mso-bidi-font-style:italic">Quercus robur</span></i> L.<span style="mso-bidi-font-style:italic">, </span><i style="mso-bidi-font-style:normal">Salvia officinalis </i>L.<i style="mso-bidi-font-style:normal">, <span style="mso-bidi-font-weight:bold">Olea europaea</span></i><span style="mso-bidi-font-weight:bold"> L.</span>, <i><span style="mso-bidi-font-weight: bold">Polygonum aviculare</span></i>L., <i>Calendula</i><i style="mso-bidi-font-style: normal"> officinalis</i> L.<i style="mso-bidi-font-style:normal">, Matricaria chamomilla</i> L. andessential oils of <i style="mso-bidi-font-style:normal">Melaleuca alternifolia</i>, </span></b><b style="mso-bidi-font-weight:normal"><i style="mso-bidi-font-style:normal"><span lang="HR" style="font-size:10.0pt; mso-ansi-language:HR">Thymus vulgaris</span></i></b><b style="mso-bidi-font-weight: normal"><span style="font-size:10.0pt;mso-ansi-language:EN-US"> ct<i style="mso-bidi-font-style:normal">. </i>Thymol and <i style="mso-bidi-font-style: normal">Origanum vulgare </i>for the treatment of hemorrhoids of grade 1 to 3 as well as the comparison to the standard treatment approach. The experimental group consisted of 66 participants was treated with Bioapifit</span></b><b style="mso-bidi-font-weight:normal"><sup><span style="font-size:10.0pt; font-family:Symbol;mso-ascii-font-family:"Times New Roman";mso-hansi-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-char-type:symbol;mso-symbol-font-family: Symbol"><span style="mso-char-type:symbol;mso-symbol-font-family:Symbol">Ò</span></span></sup></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;mso-ansi-language: EN-US"> ointment while the control group consisted of 40 participants was treated with Faktu</span></b><b style="mso-bidi-font-weight:normal"><sup><span style="font-size:10.0pt;font-family:Symbol;mso-ascii-font-family:"Times New Roman"; mso-hansi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-char-type: symbol;mso-symbol-font-family:Symbol"><span style="mso-char-type:symbol; mso-symbol-font-family:Symbol">Ò</span></span></sup></b><b style="mso-bidi-font-weight: normal"><span style="font-size:10.0pt;mso-ansi-language:EN-US"> ointment (50 mg/g of policresulene and 10 mg/g of </span></b><b style="mso-bidi-font-weight: normal"><span lang="HR" style="font-size:10.0pt;mso-ansi-language:HR;mso-bidi-font-style: italic">cinchocaine</span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;mso-ansi-language:EN-US">)<i style="mso-bidi-font-style: normal">. </i><span style="mso-bidi-font-weight:bold">Either </span>Bioapifit</span></b><b style="mso-bidi-font-weight:normal"><sup><span style="font-size:10.0pt; font-family:Symbol;mso-ascii-font-family:"Times New Roman";mso-hansi-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-char-type:symbol;mso-symbol-font-family: Symbol"><span style="mso-char-type:symbol;mso-symbol-font-family:Symbol">Ò</span></span></sup></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;mso-ansi-language: EN-US"> or Faktu</span></b><b style="mso-bidi-font-weight:normal"><sup><span style="font-size:10.0pt;font-family:Symbol;mso-ascii-font-family:"Times New Roman"; mso-hansi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-char-type: symbol;mso-symbol-font-family:Symbol"><span style="mso-char-type:symbol; mso-symbol-font-family:Symbol">Ò</span></span></sup></b><b><span style="font-size:10.0pt;mso-ansi-language:EN-US">ointment was applied externally three times a day for ten days onto clean perianal area and rectally once a day (before bedtime) using appropriate applicator. </span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;mso-ansi-language: EN-US">The evaluation of the patients before and following the therapy was done in terms of pain, defecation discomfort, bleeding severity, anal itching severity and overall subjective discomfort. </span></b><b><span lang="SR" style="font-size:10.0pt">After three days of the therapy </span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;mso-ansi-language: EN-US">the mean values and standard deviations in the experimental group for pain, <span style="mso-bidi-font-weight:bold">defecation discomfort, </span>bleeding, itching and overall subjective discomfort <span style="mso-bidi-font-weight: bold">decreased from </span>6.6±0.9<span style="mso-bidi-font-weight:bold">, </span>6.9±1.0<span style="mso-bidi-font-weight:bold">, </span>2.2±0.7<span style="mso-bidi-font-weight: bold">, </span>2.6±0.6<span style="mso-bidi-font-weight:bold">and </span>7.0±0.8, respectively to2.2±0.8<span style="mso-bidi-font-weight:bold">, </span>2.5±1.0<span style="mso-bidi-font-weight:bold">, </span>0.6±0.5<span style="mso-bidi-font-weight: bold">, </span>1.3±0.7 <span style="mso-bidi-font-weight:bold">and </span>3.0±0.8<span style="mso-bidi-font-weight:bold">, respectively. </span>At 10<sup>th</sup> day of the treatment all five parameters were graded 0 by all 66 patients. The control group <span style="mso-bidi-font-weight:bold">also showed a significant decrease of all five parameters after only three days of the therapy while in the end of the treatment overall subjective symptoms decreased from</span> 3.8<span style="mso-bidi-font-weight:bold">±</span>1.0 to 0.9<span style="mso-bidi-font-weight: bold">±</span>0.9. Bioapifit</span></b><b style="mso-bidi-font-weight:normal"><sup><span style="font-size:10.0pt;font-family:Symbol;mso-ascii-font-family:"Times New Roman"; mso-hansi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-char-type: symbol;mso-symbol-font-family:Symbol"><span style="mso-char-type:symbol; mso-symbol-font-family:Symbol">Ò</span></span></sup></b><b style="mso-bidi-font-weight: normal"><span style="font-size:10.0pt;mso-ansi-language:EN-US"> ointment was found superior to Faktu</span></b><b style="mso-bidi-font-weight:normal"><sup><span style="font-size:10.0pt;font-family:Symbol;mso-ascii-font-family:"Times New Roman"; mso-hansi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-char-type: symbol;mso-symbol-font-family:Symbol"><span style="mso-char-type:symbol; mso-symbol-font-family:Symbol">Ò</span></span></sup></b><b><span style="font-size:10.0pt;mso-ansi-language:EN-US">ointment in the treatment of </span></b><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;mso-ansi-language: EN-US">the symptoms of hemorrhoidal disease.<span style="mso-bidi-font-weight: bold"><o:p></o:p></span></span></b></p>
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Download PDF Journal DOI : 10.15373/2249555XCite This Article:
Orescanin Visnja, Findri Gustek Stefica, Rodic Josipa, BIOAPIFIT ANTI-HEMORRHOIDAL OINTMENT EFFICIENCY‾A COMPARISON WITH STANDARD APPROACH, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-7 | Issue-9 | September-2018